The Limb Skeletal Cell Atlas is an initiative to integrate publicly available single-cell RNA-seq datasets from skeletal and limb developmental studies. The atlas is an interactive web-based resource to facilitate accessibility of genomics data. Users can interactively identify cell types expressing genes of interest or discover transcriptomic subpopulations within a cell type.

The LSCA can be downloaded at skeletalcellatlas.org. The source code of the web app, all code used to perform the analyses and notebooks to generate the figures are available on GitHub: https://github.com/mbarzegary/skeletal-cell-atlas (web app) and https://github.com/TElabSBE/LimbSkeletalCellAtlas (analyses and figures).

You can read the publication here.

Interested in contributing to the atlas? Contact us!

When using the LSCA in your research, we kindly ask you to cite:

Herpelinck, T., Ory, L., Verbraeken, T. et al. A single-cell atlas of the murine limb skeleton integrating the developmental and adult stages. Sci Rep 15, 22514 (2025). https://doi.org/10.1038/s41598-025-05277-6