Laura Lafuente Gracia

PhD Researcher

In silico modeling of the influence of scaffold properties on the in vivo tissue regeneration response in large skeletal defects

    • Tissue engineering
    • Bone regeneration
    • Mathematical and computational modelling
    • Mathematical biology
    • In silico medicine
    • Computational biomechanics

Bone tissue engineering (TE) uses a combination of cells, biomaterials and growth factors for the treatment of large bone defects, meaning that we have several processes occurring at tissue, cell and intracellular levels together. In order to understand them and be able to predict their behavior, multiscale mathematical models can be used. So far some successful results have been published, but bone TE still suffers from unpredictable and qualitatively inferior results. In this thesis we will combine a detailed description of a biomaterial behavior in vivo with a model of the biological response to said biomaterial, with the aim to generate an enhanced bioregulatory model which can predict highly qualitative TE solutions.

  • M.Sc. in Biomedical Engineering, 2019
    University of Zaragoza, Spain
    Specialization: Advanced Biomechanics and Biomaterials
    Thesis: “Where shall I go? The mechanosening adventures of a computational single cell”
    Erasmus exchange (2018-2019): KU Leuven, Belgium
  • B.Sc. in Mathematics, 2017
    University of Zaragoza, Spain
    Thesis: “Mathematical study of the disease diffusion”
    Erasmus exchange (2016-2017): TU München, Germany

laura.lafuentegracia [at]

Biomechanics Section
Celestijnenlaan 300 – box 2419
3001 Leuven (Belgium)
Room: 04.114