• Cell biology
• Cell Therapy
• Bone and cartilage regeneration
• Clinical translation

This PhD-project focuses on the culture of craniofacial human periosteum-derived cells and and exploring the differences between craniofacial-derived cells and tibial-derived cells. Furthermore, we will optimise culturing strategies by selecting the best combination and dosis of growth factors and select the best scaffolds to use. The obtained tissue-engineered constructs will be tested in an orthotopic rat model for craniofacial bone defects, which will be developed and validated.

• 2015: Master’s degree in Medicine, obtained at Erasmus University Rotterdam
• 2017: Master’s degree in Molecular Medicine, obtained at Erasmus University Rotterdam
• 2019: Master’s degree in Dentistry, obtained at KU Leuven

• Groeneveldt LC, Knuth C, Witte-Bouma J, O’Brien FJ, Wolvius EB, Farrell E: Enamel Matrix
  Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells.
  Frontiers in Bioengineering and Biotechnology 2:29, 2014
• Spiegelberg L, Braks JA, Groeneveldt LC, Djasim UM, van der Wal KG, Wolvius EB. Hyperbaric
  oxygen therapy as a prevention modality for radiation damage in the mandibles of mice. Journal
  of cranio-maxillo-facial surgery. 32: 214, 2015
• Smeets M, Gemels B, Groeneveldt L, Politis C: Is there need for technical investigations in order
  to predict potential length of hospital stay of oral infections? American Journal of Emergency
  Medicine, 2019 Feb;37(2):231-236. doi: 10.1016/j.ajem.2018.05.034. Epub 2018 Jun 10.
• Groeneveldt LC, Herpelinck T, Maréchal M, Politis C, van IJcken WFJ, Huylebroeck D, Geris L, Mulugeta E, Luyten FP
  The Bone-Forming Properties of Periosteum-Derived Cells Differ Between Harvest Sites
  Frontiers in Cell and Developmental Biology 2020 Nov 25;8:554984. doi: 10.3389/fcell.2020.554984. eCollection 2020.

lisanne.groeneveldt [at] kuleuven.be