Lymphatic vessels have an important role in inflammation and are considered as potential therapeutic targets for inflammatory pathologies. In this project, dual in silico/in vitro approaches will be used to investigate the interplay between lymphangiogenesis and inflammation. We will first develop a virtual lymphatic endothelial cell (LEC) model to investigate the effect of inflammation on the intracellular regulation of the cells. In addition, we will develop an agent-based model representing the LECs, immune actors and the inflamed media interactions. A counterpart in vitro model will be developed using microfluidic chips.

• In silico modeling
• Systems biology
• Dual in vitro/in silico approaches
• Lymphangiogenesis

• Master of Science (MSc) in Biomedical Engineering, 2022
  University of Liège, Belgium
• Bachelor of Science (BSc) in Engineering, 2020
  University of Liège, Belgium

List of publications

lcomeliau[at]uliege.be

Biomechanics Research Unit, GIGA In silico Medicine, University of Liège, CHU-B34, +5. Quartier Hôpital, Avenue de l’Hôpital, 11, 4000 Liège, Belgium.

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