• Bone tissue engineering
• 3D printing
• Computational modelling

Healing large bone defects remains a challenge for clinicians and patients, primarily due to the limited availability of autologous bone grafts. Therefore, the use of scaffolds as carrier structures is a common practice. Among other functionalities, the scaffold should provide sufficient mechanical properties to endure physiological loading and offer enough porosity and surface area for nutrient and oxygen delivery, waste disposal, cell attachment, and bone growth. A proper design can be achieved by optimizing the bone scaffold’s geometry for sufficient strength, porosity, and material choice, while ensuring manufacturability. Therefore, the scope of my thesis proposes the design of bone scaffolds with optimal pore sizes, considering a mechanobiological model to maximize bone formation. Once the optimized bone scaffold geometry is obtained, the 3D printing process will be further optimized for the scaffolds. These scaffolds will then be used for cell culture to assess cell attachment and undergo mechanical characterization.

PhD: Materials Science and Nano Engineering, Sabanci University, Istanbul, present
Visiting researcher at KU Leuven: May 2022 – January 2023 and May 2024

M.Sc.: Biomedical Engineering, TOBB ETU, Ankara, Turkey, 2018

B.Sc.: Biomedical Engineering, TOBB ETU, Ankara, Turkey, 2016

M.S. Aydin, M.Sahin, Z. Dogan, and G.Kiziltas. ’Microstructural Characterization of PCL-HA Bone Scaffolds Based on Nonsolvent-Induced Phase Separation’. ACS Omega 2023 8 (50), 47595-47605. DOI: 10.1021/acsomega.3c05616

M. Sahin, A.F. Tabak, G.K. Sendur. ‘Initial Study Towards the Integrated Design of Bone Scaffolds Based on Cell Diffusion, Growth Factor Release and Tissue Regeneration’. Proceedings of the ASME 2020 International Mechanical Engineering Congress and Exposition IMECE2020, November 16-19, 2020, Portland, OR, USA.

Conferences:
Oral Presentations
M. Sahin, A.F. Tabak, G.K. Sendur. ‘Analysis of functionally graded and uniform scaffolds based on mechano-biology and cell diffusion’. Virtual Physiological Human-VPH 2022, Sept 6-9, 2022, Porto, Portugal.
M. Sahin, A.F. Tabak, G.K. Sendur. ‘Initial Study Towards the Integrated Design of Bone Scaffolds Based on Cell Diffusion, Growth Factor Release and Tissue Regeneration’. Proceedings of the ASME 2020 International Mechanical Engineering Congress and Exposition IMECE2020, November 16-19, 2020, Portland, OR, USA. (online)
M. Sahin, H.K. Bilgili, G.K. Sendur. ‘Design and Fabrication of Novel Functionally Graded Bone Scaffolds Using Topology Optimization’. European Orthopaedic Research Society 28th Annual Meeting, İzmir, TURKEY, September 17-18, 2020. (online)
M. Sahin, H.T. Yener, E. E. Oren. ‘Modeling and Design of Controlled Drug Release Systems’. 5TH International BAU Drug Design Congress, Istanbul, TURKEY, October 19- 21, 2017
H.T. Yener, M. Sahin, E. E. Oren. ‘Design of Controlled Drug Release Systems from Bulk Degrading Polymers’. XXV International Materials Research Congress, Cancun, August 14 – 19, 2016
E. Kayali, E. Mercan, M. Sahin, H. T. Yener, N. S. Aydin, G. K. Dogu E. E. Oren and G. C. Buke “Investigation of catalyst effect on the formation of 1D carbon nanostructures via low temperature vacuum decomposition of SiC” MRS 2015 Fall Meeting, Symposium Q: Nano carbon materials – 1D to 3D, Boston, MA, USA, November 29 – December 4, 2015.

Poster Presentations
M. Sahin, A.A. Ghassabi, A.F. Tabak, G. K. Sendur. ‘Mesenchymal Stem Cell Diffusion Integrated Mechano-Biology’, TERMIS EU 2022 Krakow, Poland, June 28-July 1, 2022.
M. Sahin, M.S. Aydin, G. K. Sendur. ‘Design of Novel Scaffolds for Effective Healing of Bone Fractures Using Topology Optimization Based on Mechano-Biological Models and Angiogenesis’, Technical University of Denmark, Topology Optimization PhD Course, Copenhagen, Denmark, June 19-25, 2019.
M. Sahin, H.T. Yener, E. E. Oren. ‘Modeling and Design of Controlled Drug Release Systems’. 5TH International BAU Drug Design Congress, Istanbul, Turkey, October 19- 21, 2017.
M. Sahin, H.T. Yener, E. E. Oren. ‘Modeling of Morphological Evolution of Catalyst for the Synthesis of 1D Carbon Nanostructures on SiC’. Materials Research Society Fall Meeting & Exhibit. Boston, MA, USA, November 29 – December 4, 2015.

msahin [at] sabanciıuniv.edu

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