Bernard Staumont, Luiz Ladeira, Alessio Gamba and Liesbet Geris, among other co-authors, have published a paper in the journal Alternatives to Animal Experimentation (ALTEX). The title of the paper is “Mapping physiology: A systems biology approach for the development of alternative methods in toxicology”. The full publication can be read here.

The paper introduces Physiological Maps (PMs), in silico tools that visually represent biological processes and interactions within specific organs and cells. PMs use standardized formats and annotations, making them easy to share and understand. By providing insights into human biology, PMs complement and enhance new approach methodologies (NAMs), including adverse outcome pathways (AOPs), in vitro experiments and in silico models, aiming to improve predictions of chemical toxicity.

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